St. Joseph Hospital of Orange
1100 West Stewart Dr, Orange, CA 92868714.633.9111
About Us News Room Careers Contact Us
Find St. Joseph Hospital Services Our Doctors Our Services For Patients For Visitors For Community
Neuro-Oncology Program
Neuro-Oncology Program
Our Experts
Meet our Nurse Navigator
Meet our Patient Support Experts
Clinical Services
Medical Oncology
Primary Brain Cancer
Primary Central Nervous System Lymphoma
Neurosurgery
Radiation Oncology
Radiology/Imaging
Clincial Trials
Glossary of Terms
Patient and Family Resources
Publications

Share this page:

Facebook
Twitter
Google +

Primary Central Nervous System Lymphoma

The following chemotherapy and biologic therapy drugs are used to treat primary central nervous system lymphoma.

  • Rituximab (Rituxan) is given intravenously. It is an antibody protein that specifically targets B-cell lymphoma and cause cancer cell death.
    • Common side effects may include infusion reaction (may include fever, chills, headache, itching, hives, nausea, low blood pressure, shortness of breath).
    • Less common side effects may include infection, low white blood cell count, severe infusion reaction, and acute renal failure from tumor lysis syndrome.
  • Methotrexate is an intravenous chemotherapy drug. It inhibits the mechanism of folic acid, causing DNA synthesis interruption and inhibits cellular replication.
    • Common side effects may include nausea, vomiting, tiredness, low blood count, liver function abnormality, appetite loss.
    • Less common side effects may include infection, mouth sores.
    • Rare side effects may include acute liver failure, acute kidney failure, and lung damage.
  • Temozolamide (Temodar) is an oral drug that interferes with DNA synthesis and cellular replication.
    • Common side effects may include nausea, vomiting, tiredness, hair loss, appetite loss, headache, constipation.
    • Less common side effects may include convulsion, severe headache, severe fatigue, low blood count, infection.
    • Rare side effects may include pneumonia due to Pneumocystis carinii organism.
  • Cytarabine (Ara-C) is an intravenous chemotherapy drug. It interferes with DNA synthesis and inhibits cellular replication.
    • Common side effects may include nausea, vomiting, tiredness, appetite loss, mouth sores, diarrhea, fever, skin rash, liver function abnormality, low blood count.
    • Less common side effects may include skin ulceration, abdominal pain, eye irritation, infection, hair loss.
    • Rare side effects may include bowel perforation, acute kidney failure, and neurotoxicity.
  • Vincristine is an intravenous chemotherapy drug. It interferes with a cell division process.
    • Common side effects may include nerve damage, constipation, hair loss, tiredness, appetite loss.
    • Rare side effects include tissue damage when the drug leaks outside of blood vessel, hyponatremia, permanent nerve damage.
  • Procarbazine (Mutalane) is an oral chemotherapy drug. It interferes with DNA synthesis and cellular replication.
    • Common side effects may include nausea, vomiting, tiredness, appetite loss.
    • Less common side effects may include low blood count, infection.